Spare receptor theory
WebClark’s theory of occupancy may also be used for examining responses, ... This phenomenon is called the spare receptor concept or receptor reserve. It is demonstrated … Web1. feb 2005 · As found, the spare receptor theory explains how pregnancies cope with such extreme variations in concentration. Under the spare receptor theory, when a small …
Spare receptor theory
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WebAbstract. The present study provides a new concept of the spare receptor. Model [A]: 1) Several receptors connect with an effector; 2) if an agonist occupies one of the receptors … WebSpare receptors It is quite common for full agonists to achieve their maximal effect without occupying all of the relevant receptors of a cell. This is because extra receptors are …
WebChapter 2 summarizes available methods for determining receptor specificity, the affinity of the putative receptor for its specific agonist, partial agonist, and antagonist agents based … Web27. nov 2024 · In the cardiovascular system, spare adenosine receptors appear to compensate for a low extracellular adenosine level and/or a low adenosine receptor number, such as in coronary artery disease...
WebA drug receptor is a specialized target macromolecule that binds a drug and mediates its pharmacological action. These receptors may be enzymes, nucleic acids, or specialized membrane-bound proteins. The formation of the drug-receptor complex leads to … Web28. mar 2012 · Seemingly, hCG levels rise differently among different pregnancies. As found, the spare receptor theory explains how pregnancies cope with such extreme variations in concentration. Under the spare receptor theory, when a small proportion of receptors is activated it may yield similar cellular response to when all receptors are activated [49–51].
WebThe term half maximal effective concentration (EC50) refers to the concentration of a drug, antibody or toxicant which induces a response halfway between the...
WebClinical significance: The spare receptor concept could explain why the sensitivity of tissue depend on both affinity of drug & total number of receptor. It is possible to change the … terpin animalWebbe directly proportional to the extent of receptor occupancy (21). In 1956, R. P. Stephenson modified the receptor theory to account for his observations of a receptor reserve (22). A key concept of his spare receptor model is that a maximal response can be achieved by an agonist occupying only a small proportion of the receptors. terpikat senyummuWeb1. apr 1993 · However, the first recognition of “receptor reserve” or “spare receptors” mainly by Furchgott and Stephenson in separate studies about two decades ago has profoundly modified the original receptor occupancy theory, that is, the receptor occupancy is not directly proportional to the responses, and the ED 50 (orEC 50) could be much lower ... terpindaWeb15. nov 2015 · • spare receptors exist when maximum drug response is achieved prior to saturation of all receptors. 5. •they are not hidden receptors. •when they are occupied … terpinda meaningWebTo date, the receptor reserve phenomenon has been characterized in an increasing number of receptor systems. In theory, spare receptors may influence the profile of dose … terpilihnya gus dur adanyaWebSpare receptors If, as in the above example, some of the receptors can be in-activated without a decrease in the maximal effect, the dis-pensble receptor fraction is commonly referred to as `spare receptors'. Despite its widespread use in the literature, the term is not very precisely defined, and some argument ex-ists about its proper use. terpinggirkanWeb1. dec 1979 · Spare Receptors Spare Receptors Madsen, B. W. 1979-12-01 00:00:00 A recent publication in the Clinical and Experimental Pharmacology & Physiology by Ferguson et al. … terpesona senyumanmu iqiyi