Buthionine sulfoximine bso
WebDownload scientific diagram Buthionine sulfoximine (BSO) treatment decreases colonic mucosal glutathione (GSH) and glutathione disulfide (GSSG) concentrations and oxidizes colonic GSH/GSSG redox ... WebDavid K. Rassin, in Methods in Neurosciences, 1996 Inhibitory Agents. Agents that inhibit the synthesis of glutathione have been particularly useful in elucidating the metabolism of this tripeptide (47).The most widely used inhibitor has been buthionine sulfoximine (BSO), an analog of the glutamine synthetase (glutamate–ammonia ligase) inhibitor methionine …
Buthionine sulfoximine bso
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WebAug 20, 2024 · We pre-treated HeLa cells with buthionine sulfoximine (BSO) or a vehicle for 48 h to inhibit glutathione production and then expressed 3 × Flag-ATG14 or an empty vector for 24 h. Subsequently, cells were infected with CVB3 for 7 h and cell lysates were harvested for Western blot analysis ( Figure 5 C). WebL-BSO, L- Buthionine Sulfoximine. Empirical Formula (Hill Notation): C 8 H 18 N 2 O 3 S. CAS Number: 83730-53-4. Molecular Weight: 222.31. Product Comparison Guide. Use the product attributes below to configure the comparison table. (Select up to 3 total.) Select Attribute. Select Attribute. Select Attribute.
WebSep 10, 2007 · To this end, HH514 cells were cultivated in the presence of various L-buthionine-sulfoximine (BSO) concentrations, and the number of viable and dead cells was determined over a period of 8 days ... WebJul 19, 2011 · L-Buthionine-sulfoximine (BSO) is a sulfoximine used in chemotherapy, which irreversibly inhibits g-glutamylcysteine synthetase, thereby depleting cells of glutathione (GSH), a metabolite that plays a critical role in protecting cells against oxidative stress and resulting in free radical-induced apoptosis. Elevated GSH levels are …
WebDec 30, 2024 · To deepen the mechanism of EVOOE antioxidant response in RT112 and J82 cells, we employed two modulators of GSH synthesis, the GSH precursor N-acetylcysteine (NAC) and the GSH inhibitor buthionine sulfoximine (BSO). WebApr 6, 2024 · BSO, L-buthionine sulfoximine; COX1, cytochrome c oxidase subunit 1; SDH-A, succinate dehydrogenase subunit A. Figure 5. Effects of adenosine on the …
WebJun 19, 2024 · Cardenolide biosynthesis was restored by buthionine sulfoximine (BSO) treatment in Dl P5βR2-RNAi lines but not in Dl P5βR1-RNAi lines. Since progesterone is a precursor of cardenolides but can also act as a reactive electrophile species (RES), we here discriminated between these by comparing the effects of progesterone and methyl vinyl …
WebThe most widely used inhibitor has been buthionine sulfoximine (BSO), an analog of the glutamine synthetase (glutamate–ammonia ligase) inhibitor methionine sulfoximine. Administration of BSO effectively inhibits γ -glutamylcysteine synthetase by binding to the enzyme. BSO effectively reduces GSH synthesis in brain of newborn animals, but is ... bounce off game reviewsWebExperiments were carried out to investigate whether or not depletion of the glutathione (GSH) level in Drosophila melanogaster larvae with buthionine sulfoximine (BSO) treatment can result in the modulation of the frequency of sex-linked recessive lethal (SLRL) mutations induced by gamma-radiation. guardians of the galaxy game play slotsWebSep 29, 2024 · LPS, lipopolysaccharide; BSO, buthionine sulfoximine. The whole list of the 124 + 177 LPS-regulated transcripts affected by BSO at 2 and 6 h is provided in File S1 in Supplementary Material. It can be noted that, for most of the transcripts regulated by LPS, BSO antagonized the effect of LPS on gene expression rather than amplifying it, showing ... guardians of the galaxy game how longWebCAS: 83730-53-4: Molecular Formula: C 8 H 18 N 2 O 3 S: Molecular Weight (g/mol) 222.31: MDL Number: MFCD00067000: InChI Key: KJQFBVYMGADDTQ-CVSPRKDYSA-N: Synonym: l-buthionine-sulfoximine, l-buthionine sulfoximine, 2s-2-amino-4-butylsulfonimidoyl butanoic acid, l-buthionine-s,r-sulfoximine, l-buthionine s,r … guardians of the galaxy game gold guyWebBSO (L-Buthionine-(S,R)-sulfoximine, L-Buthionine sulfoximine, l-BSO) is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase … guardians of the galaxy game itemsWebJul 18, 2014 · Powdered L-PAM and BSO (DL buthionine-(S,R)-sulfoximine) were purchased from Sigma-Aldrich (St Louis, MO, USA) … bounce off of synonymWebApr 16, 2024 · Blocking GSH production through use of l -buthionine sulfoximine (BSO), an inhibitor of the catalytic subunit of GCL (GCLC), has been proposed as a cancer therapy strategy. However, it is not ... guardians of the galaxy game grand unifier